Appendix Table 1.

Central Nervous System Penetration Effectiveness Rankings of Frequently Used Antiretroviral Regimen (10)

Antiretroviral Class	Central Nervous System Penetration Effectiveness Rankinga
	4	3	2	1
Nucleoside analogue reverse transcriptase inhibitors	Zidovudine	Abacavir	Didanosine	Tenofovir
		Emtricitabine	Lamivudine	Zalcitabine
			Stavudine
Nonnucleoside analogue reverse transcriptase inhibitors	Nevirapine	Delavirdine	Etravirine
		Efavirenz
Protease inhibitors	Indinavir/ritonavir	Darunavir/ritonavir	Atazanavir	Nelfinavir
		Fosamprenavir/ritonavir	Atazanavir/ritonavir	Ritonavir
		Indinavir	Fosamprenavir	Saquinavir
		Lopinavir/ritonavir		Saquinavir/ritonavir
				Tipranavir/ritonavir
Entry/fusion inhibitors		Maraviroc		Enfuvirtide
Integrase strand transfer inhibitors		Raltegravir

^a Higher rankings reflect better central nervous system penetration estimates.