Table 1.
Characteristics of the study populations from the ALSPAC cohort
| Discovery & Validation sample (n = 88) † | Replication sample (n = 170) | Rest of eligible (n = 1991) § | |
|---|---|---|---|
|
Child’s sex, male (%) |
51.1 |
50.6 |
49.5 |
|
Age of mother at birth, mean (sd) |
30.6 (3.3) |
28.7 (4.4) |
27.4 (5.1) |
|
Maternal pre-pregnancy BMI (kg/m
2
) |
|
|
|
| Mean (sd) |
22.2 (3.05) |
23.8 (4.1) |
23.1 (3.9) |
| Normal, 18.5-24.9, (%) |
85.9 |
68.6 |
73.6 |
| Underweight, < 18.5, (%) |
1.2 |
2.4 |
4.8 |
| Overweight, 25.0-29.9, (%) |
10.6 |
20.7 |
15.5 |
| Obese, ≥ 30, (%) |
2.4 |
8.3 |
6.1 |
|
GWG (kg/wk) |
|
|
|
| 0 to 18 weeks |
|
|
|
| Mean (sd) |
0.32 (0.17) |
0.31 (0.18) |
0.30 (0.18) |
| Median |
0.33 |
0.32 |
0.31 |
| Min, Max |
-0.33, 0.83 |
-0.22, 0.79 |
-0.64, 1.31 |
| 19-28 weeks |
|
|
|
| Mean (sd) |
0.55 (0.17) |
0.54 (0.16) |
0.53 (0.18) |
| Median |
0.55 |
0.53 |
0.53 |
| Min, Max |
0.22, 1.00 |
0.14, 0.96 |
-0.18, 1.45 |
| 29 weeks onwards |
|
|
|
| Mean (sd) |
0.49 (0.18) |
0.47 (0.20) |
0.46 (0.21) |
| Median |
0.47 |
0.45 |
0.45 |
| Min, Max |
-0.02, 0.95 |
0.03, 1.04 |
-0.54, 1.22 |
| IoM categories, (%) |
|
|
|
| Recommended |
36.6 |
37.3 |
36.1 |
| Less than recommended |
34.1 |
31.9 |
35.8 |
| More than recommended | 29.3 | 30.8 | 28.1 |
† 4 subjects initially included in the discovery study (n = 88) failed in the validation study.
§ Participants of the ALSPAC cohort with available cord blood DNA.