Table 3.
Validation study: associations of maternal pre-pregnancy BMI and gestational weight gain (GWG) with MMP7 CpG sites methylation levels in newborn cord blood DNA
| |
CpG1 |
CpG2 |
CpG3 (E59) |
Mean of 3 CpGs |
||||
|---|---|---|---|---|---|---|---|---|
| Coef a (se) | p value | Coef a (se) | p value | Coef a (se) | p value | Coef a (se) | p value | |
|
Pre-pregnancy BMI (n = 87) |
0.80 (0.70) |
0.250 |
1.15 (0.78) |
0.143 |
1.22 (0.82) |
0.139 |
1.06 (0.75) |
0.158 |
|
GWG 0 to 18 wks (n = 84) |
0.80 (1.99) |
0.686 |
1.52 (2.27) |
0.505 |
2.44 (2.36) |
0.302 |
1.59 (2.15) |
0.461 |
|
GWG 19 to 28 wks (n = 84) |
0.96 (1.73) |
0.580 |
2.89 (1.95) |
0.141 |
2.83 (2.04) |
0.167 |
2.23 (1.86) |
0.232 |
|
GWG 29 wks. onwards (n = 84) |
2.38 (1.57) |
0.133 |
3.25 (1.79) |
0.071 |
3.90 (1.85) |
0.037 |
3.17 (1.69) |
0.062 |
|
GWG IoM categories (n = 78) |
|
|
|
|
|
|
|
|
| Recommended |
0 [Ref.] |
|
0 [Ref.] |
|
0 [Ref.] |
|
0 [Ref.] |
|
| Less than recommended |
2.03 (1.74) |
0.246 |
0.18 (2.00) |
0.930 |
0.38 (2.09) |
0.853 |
0.86 (1.90) |
0.649 |
| More than recommended | 3.35 (1.79) | 0.063 | 3.13 (2.06) | 0.131 | 3.81 (2.16) | 0.080 | 3.43 (1.96) | 0.082 |
aRegression coefficient using linear mixed models. For pre-pregnancy BMI (kg/m2) estimated changes per 1 SD change and for GWG estimated changes per additional 400 g/week.
All models adjusted for child’s sex and maternal age and the inclusion of a PCR plate random batch effect.