Table 4.
Replication study: associations of maternal pre-pregnancy BMI and gestational weight gain (GWG) with MMP7 CpG sites methylation levels in newborn cord blood DNA (n = 170)
| |
CpG1 |
CpG2 |
CpG3 (E59) |
Mean of 3 CpGs |
||||
|---|---|---|---|---|---|---|---|---|
| Coef a (se) | p value | Coef a (se) | p value | Coef a (se) | p value | Coef a (se) | p value | |
|
Pre-pregnancy BMI |
-0.03 (0.57) |
0.952 |
-0.44 (0.66) |
0.501 |
-0.48 (0.69) |
0.486 |
-0.31 (0.62) |
0.613 |
|
GWG 0 to 18 wks. |
-0.34 (1.28) |
0.791 |
-0.62 (1.46) |
0.671 |
-0.76 (1.55) |
0.621 |
-0.58 (1.39) |
0.674 |
|
GWG 19 to 28 wks. |
-0.25 (1.45) |
0.863 |
-1.04 (1.65) |
0.528 |
-0.46 (1.75) |
0.790 |
-0.60 (1.56) |
0.702 |
|
GWG 29 wks. onwards |
0.57 (1.16) |
0.622 |
0.42 (1.33) |
0.751 |
0.01 (1.41) |
0.994 |
0.34 (1.26) |
0.787 |
|
GWG IoM categories |
|
|
|
|
|
|
|
|
| Recommended |
0 [Ref.] |
|
0 [Ref.] |
|
0 [Ref.] |
|
0 [Ref.] |
|
| Less than recommended |
-2.00 (1.37) |
0.144 |
-1.54 (1.56) |
0.323 |
-1.62 (1.65) |
0.329 |
-1.71 (1.48) |
0.249 |
| More than recommended | -1.85 (1.39) | 0.185 | -2.07 (1.59) | 0.195 | -2.24 (1.68) | 0.185 | -2.04 (1.51) | 0.177 |
aRegression coefficient using linear mixed models. For pre-pregnancy BMI (kg/m2) estimated changes per 1 SD change and for GWG estimated changes per additional 400 g/week.
All models adjusted for child’s sex and maternal age and the inclusion of a PCR plate random batch effect.