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. 2014 Mar 20;9:66. doi: 10.1186/1746-1596-9-66

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Copyright © 2014 Liu et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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DNA methylation levels closely correlate with gene expression, histone modification and short RNA expression. (a) The methylation level of genes with high (red line), medium (orange line) and low (blue line) expression levels. (b) The TSS region and latter half of the gene body show differential DNA methylation levels that correspond to gene expression level. (c) Comparison of DNA methylation levels within and without differentially histone bound regions. The histone modifications analyzed include histone acetylation and methylation. (d) The percentage of CCGG sites located in and near short RNA coding regions. (e) The overall methylation level of CCGG sites that are within, near and without short RNA coding regions.