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. 2014 Mar 20;9:66. doi: 10.1186/1746-1596-9-66

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Copyright © 2014 Liu et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Comparison of genome-wide DNA methylation of A549 cells before and after EMT. (a) The average methylation level of 200-bp windows (violet red dots) and CGIs (cyan dots) of S4h, S12h, S24h and S96h compared with S0h. A 25% difference boundary line is shown (black line). (b) Example regions to show that the average methylation level of the 200 bp windows is similar in S0h (blue line) and S24h (violet red line). (c) The average methylation level of CGIs that were hypo-, semi- and hypermethylated in primary A549 cells. The data of 100 CGIs are shown as examples.