Table 2.
Bivariate and multivariate associations with acute kidney injury
| Variable | OR | 95% CI | p | aOR | 95% CI | p |
|---|---|---|---|---|---|---|
| Age group | ||||||
| Young (reference) | 1.00 | N/A | N/A | 1.00 | N/A | N/A |
| Older adults | 1.00 | 0.41–2.42 | 1.00 | 0.69 | 0.25–1.92 | 0.48 |
| Very elderly | 0.90 | 0.37–2.20 | 0.82 | 0.78 | 0.28–2.26 | 0.80 |
| CrCl (mL/min) | 0.98 | 0.96–1.00 | 0.05 | – | – | – |
| Charlson score | 1.30 | 1.05–1.61 | 0.02 | – | – | – |
| Infection sitea | ||||||
| Blood | 0.36 | 0.14–0.94 | 0.03 | – | – | – |
| Genitourinary | 0.38 | 0.11–1.43 | 0.14 | – | – | – |
| Lower respiratory tract | 4.08 | 1.90–8.78 | <0.01 | 5.18 | 2.15–12.41 | <0.01 |
| Goal vancomycin trough 15–20 mg/L | 2.21 | 0.91–5.36 | 0.07 | – | – | – |
| Length of treatment (days) | 1.08 | 1.00–1.16 | 0.04 | 1.12 | 1.03–1.22 | <0.01 |
| Risk factors for nephrotoxicity | ||||||
| Vasopressors | 4.30 | 0.76–24.46 | 0.10 | – | – | – |
| Nephrotoxins | 2.06 | 0.98–4.35 | 0.06 | – | – | – |
| ≥2 risk factors at baseline | 7.00 | 2.08–23.55 | <0.01 | 6.94 | 1.81–26.66 | <0.01 |
aOR adjusted odds ratio, CI confidence interval, CrCl creatinine clearance, OR odds ratio
aInfection sites are not mutually exclusive. Data are median (interquartile range) or n (%)