Table 3.
C max and AUC 0-t of rHuIL-12, IFN-γ, IL-18, and IP-10 after a Single Dose of rHuIL-12 in Irradiated Rhesus Monkeys
| |
rHuIL-12 |
IFN-γ |
IL-18 |
IP-10 |
||||
|---|---|---|---|---|---|---|---|---|
| Dose (ng/kg) | C max (pg/mL) | AUC 0-t (hr · pg/mL) | C max (pg/mL) | AUC 0-t (hr · pg/mL) | C max (pg/mL) | AUC 0-t (hr · pg/mL) | C max (pg/mL) | AUC 0-t (hr · pg/mL) |
| 0 |
BLQ |
BLQ |
150.20 (NR) |
24868.80 (NR) |
1920.75 (1207.67) |
228818.77 (121013.28) |
284.36 (188.72) |
16519.02 (7951.53) |
| 50 |
14.65 (4.75) |
190.61 (90.51) |
257.73 (120.42) |
6239.20 (5395.40) |
1831.76 (1275.11) |
236796.45 (209796.17) |
1100.67 (316.73) |
43932.87 (29769.36) |
| 100 |
39.03 (15.85) |
532.72 (238.16) |
709.60 (422.55) |
22904.40 (8449.72) |
2362.16 (1028.21) |
309524.07 (123378.16) |
1422.17 (120.53) |
61099.10 (6735.34) |
| 250 |
69.49 (11.47) |
1397.30 (203.75) |
1949.15 (1200.24) |
76621.50 (41016.18) |
3037.33 (1339.84) |
391945.00 (150071.03)) |
2313.90 (1289.69) |
78442.31 (17024.71) |
| 500 | 137.18 (38.07) | 2992.78 (1307.55) | 3094.00 (1195.79) | 123995.40 (42927.08) | 4738.03 (1511.00) | 621328.60 (171280.79) | 3236.52 (3060.21) | 118595.07 (57862.00) |
All data are means (standard deviations).
Abbreviations: BLQ-Below the limit of quantitation; AUC, area under the concentration vs. time curve; 0-t, time 0 to time of assessment; hr, hour; NR, not reported due to < 3 animals contributing data.