Table 1.
General characteristics, biochemical, hemodynamic, and angiographic data according to LPA rs10455872 genotypes in the patients submitted to coronary angiography
| |
Genotypes |
p
value |
|
|---|---|---|---|
| (n=1394,100%) | AA(n=1223) | AG+GG(n=171) | |
|
Age(years) |
59.9 ± 10.1 |
59.5 ± 10.8 |
0.62 |
|
Gender,female(%) |
40.6 |
37.4 |
0.42 |
|
Race/color(%) |
|
|
|
|
White |
65.0 |
74.9 |
|
|
Intermediate |
29.8 |
23.4 |
0.02 |
|
Black |
5.2 |
1.8 |
|
|
Hypertension(%) |
70.0 |
68.4 |
0.68 |
|
Diabetes(%) |
31.2 |
27.5 |
0.33 |
|
Hyperlipidemia(%) |
57.2 |
71.3 |
0.002 |
|
Statin use(%) |
28.0 |
30.5 |
0.61 |
|
Smokers(%) |
35.6 |
38.0 |
0.44 |
|
Body mass index(Kg/m
2
) |
27.7 ± 4.8 |
27.6 ± 4.9 |
0.99 |
|
Total cholesterol(mg/dL) |
228 ± 49 |
237 ± 46 |
0.05 |
|
LDL-C(mg/dL) |
147 ± 44 |
155 ± 39 |
0.11 |
|
HDL-C(mg/dL) |
42 ± 12 |
42 ± 10 |
0.82 |
|
Triglycerides(mg/dL) |
183 ± 130 |
179 ± 108 |
0.75 |
|
Systolic blood pressure(mmHg) |
149 ± 34 |
152 ± 39 |
0.61 |
|
Diastolic blood pressure(mmHg) |
82 ± 15 |
84 ± 15 |
0.29 |
|
Ejection fraction(%) |
60.6 ± 14.4 |
56.8 ± 17.7 |
0.07 |
|
Coronary lesions(%) |
79.6 |
88.9 |
0.004 |
|
Extension score |
2.1 ± 1.6 |
2.6 ± 1.7 |
<0.001 |
|
Severity score |
1.5 ± 1.2 |
1.9 ± 1.3 |
<0.001 |
| Gensini score | 19.7 ± 28.2 | 25.7 ± 32.0 | 0.05 |
HDL-C: high density lipoprotein; LDL-C: low density lipoprotein.
Biochemical data, blood pressures, and angiographic scores were adjusted for age, gender, and race/color.
Coronary lesions frequency was compared between normal coronary arteries versus one-vessel, two-vessel, and three-vessel disease.