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Fum-PD NP treatment suppresses NF-κB activation in KRN arthritis. (A) Paws from nonarthritic and day-9 KRN serum-induced arthritic mice were stained for phospho (P)-p65 (orange). Scale bar = 200 μm. (B) Paw lysates from day-9 arthritic paws derived from different treatment groups were blotted for total IKKα, P-p65, or total p65. (C) l-NAME, but not d-NAME, reversed Fum-PD NP-mediated IKKα degradation and suppression of p65 phosphorylation.
