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. Author manuscript; available in PMC: 2014 Jul 23.
Published in final edited form as: Biochemistry (Mosc). 2013 Jul;78(7):726–735. doi: 10.1134/S0006297913070055

Figure 2. Complex Regulation of FGF by Heparan Sulfate.

Figure 2

HS within the ECM and on the cell surface can participate in regulating FGF through binding to low-affinity non-selective sites and through interactions with high-affinity sites. Binding of FGF within the ECM can sequester or store FGF for pulse release at sites of injury. Binding of FGF by HS on the cell surface can provide a means for the cell to “capture” FGF and increase the likelihood of encounter with signaling receptors where it can form high-affinity ternary complexes.