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. Author manuscript; available in PMC: 2014 Jul 23.
Published in final edited form as: Biochemistry (Mosc). 2013 Jul;78(7):726–735. doi: 10.1134/S0006297913070055

Figure 3. Inhibition of Neutrophil Elastase by Heparan Sulfate.

Figure 3

A. Space filling structures for human neutrophil elastase based on the solved X-ray crystal structure 1HNE [109], and for a heparin-derived dodecasaccharide based on NMR analysis (1HPN) [110]. B. The relative rate of human neutrophil elastase digestion of a pseudosubstrate N-Suc-(Ala)3-pNA in the presence of the indicated heparin-derived oligosaccharide. Degree of polymerization is indicated on the x-axis. Reactions were carried out for 1 h at 27°C. Experimental details of elastase enzyme assay conditions are described in [71].