Table 1.

Clinical Findings of the Major Lipodystrophy Subtypes

	CGL	FPL	AGL	APL
Age range of onset	Infancy to early childhood	Childhood through adulthood	Childhood through adulthood	Childhood through adulthood
Approximate gender distribution (male:female)	1:1-2	1:1-2a	1:3	1:4
Fat loss locations
Face and neck	X		X	X
Chest/trunk	X	+	X	X
Upper extremities	X	X	X	X
Lower extremities	X	X	X
Intra-abdominal	X		+
Fat accumulation/sparing
Face and neck		+
Hips and buttocks				+
Lower extremities				+
Intra-abdominal		+	+	+
Other findings
Accelerated linear growth	+
Acromegaloid features	+
Umbilical prominence	+
Panniculitis			+
Hepatomegaly	+	+	+
Splenomegaly	+		+
Acanthosis nigricans	+	+	+
Hirsutism	+	+	+
Hyperphagia	+	+	+
Hypogonadism	+		+
Hyperandrogenism in females	+	+

Abbreviations: AGL = acquired generalized lipodystrophy; APL = acquired partial lipodystrophy; CGL = congenital generalized lipodystrophy; FPL = familial partial lipodystrophy; X = essential finding; + = finding may be present.

^aFPL is typically more readily recognized in females and affects females more severely.