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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Am J Hematol. 2014 Apr 28;89(8):E103–E108. doi: 10.1002/ajh.23735

Figure 1.

Figure 1

Expression profile of RARA (closed circles) and RXRA (open circles) in total bone marrow cells from 197 human AML cases using Affymetrix Human Genome U133 Plus 2.0 GeneChip Arrays (* p < 0.002; ** p < 0.001).(23) B. Expression profile of RARA (closed circles) and RXRA (open circles) in total bone marrow cells from 3 MDS patients and 4 AML patients using Nanostring nCounter (each sample analyzed in technical triplicates, two way ANOVA, p < 0.001). C. Reduction in methylcellulose colony forming by 9 unique leukemia samples derived from Ctsg-PML-RARA mice when treated for 48 hours with 1 μM of indicated retinoid and then assayed in myeloid methylcellulose. D. and E. In vivo differentiation of leukemia arising in mouse 13341. Following secondary transplantation of 1 x 106 leukemia cells, mice were treated with either placebo or bexarotene days 8–10, sacrificed and analyzed on day 14.