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. Author manuscript; available in PMC: 2014 Jul 23.
Published in final edited form as: Nano Lett. 2004 Jul 13;4(8):1501–1506. doi: 10.1021/nl0493592

Figure 4.

Figure 4

Effect of the RGD island spacing on the adhesion and proliferation of preosteoblasts. Photomicrographs of MC3T3 cells adherent to the surface of gels with different RGD island spacings (A, 62; B, 78 nm), while maintaining the same bulk RGD density ([RGD] = 1.25 μg/mg polymer). Original pictures were taken after 24 h of culture (scale bar, 100 μm). Projected area (C) and growth rates (D) of MC3T3 cells adherent to gels of differing bulk densities of peptides, and varying island spacings of ligands. Asterisk (*) represents statistical significance at a level of p < 0.05.