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(A) The osteoblast proliferation rate was strongly dependent on the RGD island spacing in gels, even in the face of various bulk ligand densities (○, 0.125; ●, 1.25; □, 6.25; ■, 12.5 μg/mg polymer). (B) No simple effect of the island density on the osteoblast proliferation rate was observed (○, 0.125; ●, 1.25; □, 6.25; ■, 12.5 μg/mg polymer).
