Table 1.

Chromosomal linkage for TSAb in CXB and BXH mice immunized twice with TSHR A-subunit adenovirus. TSAb activity was measured with mouse-TSHR cells and human-TSHR cells; these data were used to calculate the TSAb ratios (human:mouse TSHR, h:m or mouse: human TSHR, m:h). Loci and chromosomal locations (megabases, Mb) are presented for LRS scores suggestive of linkage. Possible candidate genes are included with the corresponding (or likely) human (Hu) chromosome in parentheses.

Strain	LRS	Chr	Locus	Mb	Candidate	Hu
human-TSHR TSAb
BXH a	13.628	12	rs13459138	113.270	Igh V genes	14
			rs3705923	117.869	Igh V genes
			rs3692361	118.161
			rs3679276	120.329
CXB	16.787	17	gnf17.035.152	34.663	MHC region	6
			rs6395893	38.786	genes
			D17Mit66	47.186
			rs3690039	48.900
	16.787	X	rs13483834	72.576	ll1rapl1	X
			rs13483877	83.201
mouse-TSHR TSAb
CXB	14.518	12	rs13481658	113.595	Igh V region	14
			rs3711281	118.633	genes
TSAb Ratio
BXH m:h b	20. 433	12	CEL-12_10454502266.496	110.245		14
			CEL-12_10470961366.496	110.409
			D12Mit133	110.746	(Dio3)	14
			rs13481651	111.769
	18.323	12	rs13459138	113.271	Igh V genes	14
			rs3705923	117.869	Igh V genes
			rs3692361	118.161
			rs3679276	120.329
CXB h:m	11.552	12	D12Mit132	107.374	(Dio3)	14
			rs13481636	108.001

^apreviously reported ¹⁴;

^bsimilar observations for h:m TSHR TSAb (but lower LRS values). Candidate genes: MHC region including:C2 (34.470663), Hspa1 (34.577246);Tnf (34.807461 and Ltb (34.802573); ll1rapl1, interleukin 1 receptor accessory protein-like 1; Dio3, deiodinase type 3 (110.727 Mb); Igh V region genes, immunoglobulin heavy chain variable region genes. LRS = LOD X 4.61. GeneNetwork (GN) Identifiers:- human-TSHR TSAb, BXH GN10147; CXB GN10683; mouse-TSHR TSAb, CXB GN10685; TSAb Ratio: BXH m:h GN10157; CXB h:m GN10686. No linkage was observed for BXH mouse-TSHR TSAb GN10155.