Table 2.
Combined linkage analysis for TSAb in BXH and CXB recombinant inbred mice (26 strains) immunized twice with TSHR A-subunit-adenovirus.
| Trait | Chr | Chr Interval (Mb) | X 2 | p | LOD |
|---|---|---|---|---|---|
|
| |||||
| TSAb | |||||
|
| |||||
| CXB mouse-TSHR TSAb and BXH human-TSHR TSAb |
12 | 109.730 -110.187 | 20.95 | 0.000324 | 3.490 |
| 110.245 -110.306 | 20.05 | 0.000488 | 3.312 | ||
| 110.882- 111.769 | 19.44 | 0.000643 | 3.192 | ||
| 113.181- 113.187 | 19.92 | 0.000519 | 3.285 | ||
| 113.595 -118.161 | 21.13 | 0.000298 | 3.526 | ||
|
| |||||
| Ratio | |||||
|
| |||||
| CXB human:mouse TSHR and BXH mouse:human TSHR |
12 | 108.577 - 109.137 | 21.06 | 0.00030858 | 3.511 |
| 110.306 -110.409 | 33.80 | 8.19781E-07 | 6.086 | ||
| 110.882 - 111.967 | 32.53 | 1.49236E-06 | 5.826 | ||