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. Author manuscript; available in PMC: 2014 Nov 15.
Published in final edited form as: ACS Chem Biol. 2013 Sep 27;8(11):2528–2537. doi: 10.1021/cb400431f

Figure 5.

Figure 5

Pentamidine analogs rescue mis-splicing of minigene reporters in a HeLa cell DM1 model. a) Jitter plot representation of TNNT2 splicing. Each point is one experiment and the line represents the average of all experiments for that condition (at least three for each concentration). Butamidine, pentamidine, hexamidine, and heptamidine rescued TNNT2 mis-splicing in the presence of 960 CUG repeats. Octamidine had a slight effect. b) Plots of INSR splicing. All pentamidine linker analogs are able to fully or partially rescue INSR mis-splicing in the presence of 960 CUG repeats. Gray area denotes range between typical splicing and DM mis-splicing.