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. 2014 Jul 23;9(7):e101161. doi: 10.1371/journal.pone.0101161

Figure 5. Immunohistochemistry of COX-2 in spleen, lung and heart.

Figure 5

Spleen (A), lung (B) and heart (C) tissues were collected 7 days after total body irradiation and embedded in paraffin for immunohistochemistry staining. a–d) A/J mice; e–h) BALB/c mice; a,e) sham irradiated controls; b,f) mice treated with p2TA peptide 5 mg/kg six days before tissue harvest; c,g) mice exposed to 8 Gy gamma rays seven days before the sacrifice; d,h) mice exposed to 8 Gy gamma rays that received 5 mg/kg p2TA peptide 24 hours after radiation exposure. While irradiation increases COX-2 staining in spleen, its effect on lung and heart was not marked. Administration of p2TA peptide modulated the effect of irradiation on spleen samples.