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. 2014 Jul 23;9(7):e102555. doi: 10.1371/journal.pone.0102555

Figure 1. Increased HIV-1 transcription in the brains of METH-user HIV seropositive subjects.

Figure 1

The content of HIV DNA and cellular HIV RNA was profiled in the frontal cortex area of HIV seropositive individuals with and without history of METH use, by real-time PCR and normalized to Actin or GAPDH levels respectively. A. and B. HIV-1 DNA and cellular HIV RNA did not show significant changes among groups. C. HIV-1 RNA/DNA ratio (as a marker of average HIV transcription) was significantly higher in METH user group, suggesting increases on viral transcription in the brain. *p<0.05 by Mann Whitney pairs test.