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. 2014 Jul 23;9(7):e103021. doi: 10.1371/journal.pone.0103021

Table 2. Multivariate Cox regression analysis of clinical variables on overall survival accord to (A) PIK3CA mutation status and (B) PIK3CA expression status.

Variable N Multivariate analysis
Hazard ratio 95% CI P value
(A) PIK3CA mutation status
 All ESCC patients a 406 1.256 0.748–2.108 0.388
 ESCC patients with age<59 years b 195 1.363 0.753–2.467 0.307
 ESCC patients with family history of cancer c 85 10.493 2.432–45.267 0.002
(B) PIK3CA expression status
 All ESCC patients a 406 1.072 0.794–1.447 0.651
 ESCC patients with age≥59 years b 211 1.237 0.753–2.035 0.401
 Female ESCC patients d 88 2.341 1.073–5.108 0.033
 Non-smoking ESCC patients e 151 1.144 0.665–1.968 0.627
a

Adjust by age, gender, tobacco use, alcohol use, family cancer history, tumor location, pathologic T classification, degree of differentiation, lymph node metastasis, tumor embolus and local recurrence.

b

Adjust by gender, tobacco use, alcohol use, family cancer history, tumor location, pathologic T classification, degree of differentiation, lymph node metastasis, tumor embolus and local recurrence.

c

Adjust by age, gender, tobacco use, alcohol use, tumor location, pathologic T classification, degree of differentiation, lymph node metastasis, tumor embolus and local recurrence.

d

Adjust by age, tobacco use, alcohol use, family cancer history, tumor location, pathologic T classification, degree of differentiation, lymph node metastasis, tumor embolus and local recurrence.

e

Adjust by age, gender, alcohol use, family cancer history, tumor location, pathologic T classification, degree of differentiation, lymph node metastasis, tumor embolus and local recurrence.