Table 2. Multivariate Cox regression analysis of clinical variables on overall survival accord to (A) PIK3CA mutation status and (B) PIK3CA expression status.
Variable | N | Multivariate analysis | ||
Hazard ratio | 95% CI | P value | ||
(A) PIK3CA mutation status | ||||
All ESCC patients a | 406 | 1.256 | 0.748–2.108 | 0.388 |
ESCC patients with age<59 years b | 195 | 1.363 | 0.753–2.467 | 0.307 |
ESCC patients with family history of cancer c | 85 | 10.493 | 2.432–45.267 | 0.002 |
(B) PIK3CA expression status | ||||
All ESCC patients a | 406 | 1.072 | 0.794–1.447 | 0.651 |
ESCC patients with age≥59 years b | 211 | 1.237 | 0.753–2.035 | 0.401 |
Female ESCC patients d | 88 | 2.341 | 1.073–5.108 | 0.033 |
Non-smoking ESCC patients e | 151 | 1.144 | 0.665–1.968 | 0.627 |
Adjust by age, gender, tobacco use, alcohol use, family cancer history, tumor location, pathologic T classification, degree of differentiation, lymph node metastasis, tumor embolus and local recurrence.
Adjust by gender, tobacco use, alcohol use, family cancer history, tumor location, pathologic T classification, degree of differentiation, lymph node metastasis, tumor embolus and local recurrence.
Adjust by age, gender, tobacco use, alcohol use, tumor location, pathologic T classification, degree of differentiation, lymph node metastasis, tumor embolus and local recurrence.
Adjust by age, tobacco use, alcohol use, family cancer history, tumor location, pathologic T classification, degree of differentiation, lymph node metastasis, tumor embolus and local recurrence.
Adjust by age, gender, alcohol use, family cancer history, tumor location, pathologic T classification, degree of differentiation, lymph node metastasis, tumor embolus and local recurrence.