Figure 5.
Nicotinamide inhibits growth of several clinically important pathogenic fungi. (a) Growth of azole-susceptible (AS) and azole-resistant (AR) strains (top) as well as echinocandin-susceptible (ES) and echinocandin-resistant (ER) strains (bottom), as tested in colony formation assays. Plates contained fluconazole (FLC; μg ml−1), micafungin (MCF; μg ml−1) or nicotinamide (NAM; mM). Ctl, control plates without NAM or antifugal agent. (b) Growth of two independent strains per Candida species on YPD medium containing NAM (mM). (c) Growth of two independent A. fumigatus or A. nidulans strains on complete medium containing NAM (mM).