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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Heart Rhythm. 2014 May 9;11(8):1446–1453. doi: 10.1016/j.hrthm.2014.04.042

Figure 3. Window- and Ramp-currents.

Figure 3

Window and ramp-currents of NaV1.5-R225P reveal aberrant INa at hyperpolarized potentials. (A) Overlay of Boltzmann-fitted G/V and channel availability curves of WT and R225P emphasizing window-currents. (B) Normalized TTX-subtracted average ramp-currents (0.32 mV/ms) of WT and R225P measured as a percentage of peak INa (−20mV). All data are represented as mean ± S.E.M for n=7–15 cells.