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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Semin Cancer Biol. 2014 Mar 12;0:52–61. doi: 10.1016/j.semcancer.2014.03.002

Figure 6. CRM1 bound to small molecule inhibitors.

Figure 6

A) Chemical structures of Leptomycin B (LMB), KPT-185 and KPT-251. B) Chemical reactions showing conjugation of LMB to the groove cysteine residue of CRM1 and the subsequent hydrolysis. Positions of α-protons of the Michael reaction sites are denoted by asterisks. The CRM1 NES groove bound to C) LMB (4HAT), D) KPT-185 (4GMX) E) KPT-251 (4GPT). The reactive cysteine residue in the CRM1 NES groove which these inhibitors conjugate to is labelled.