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. Author manuscript; available in PMC: 2015 Aug 12.
Published in final edited form as: J Mol Biol. 2014 Jun 6;426(16):2928–2941. doi: 10.1016/j.jmb.2014.05.028

Figure 7.

Figure 7

Schematic diagram showing the roles of Sus1p in different DNA transacting processes. Sus1p is essential for association of Ubp8p with SAGA (25). Ubp8p is dispensable for PIC formation (Figure 3C; 18), but favors transcriptional elongation (Figure 4E; 30, 31), DNA repair (Figure 5), and DNA replication (Figure 6). Sus1p also facilitates the association of Sgf73p with SAGA (Figure 3B). Sgf73p is essential for overall structural integrity of SAGA and hence PIC formation (19, 27). Thus, Sus1p appears to promote the PIC formation via Sgf73p. Sus1p and Sgf73p may also have additional direct roles in stimulation of PIC as described in the discussion section. “+”, stimulatory effect; PIC, pre-initiation complex; and ORF, open reading frame.