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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: J Pediatr Hematol Oncol. 2014 Aug;36(6):e335–e340. doi: 10.1097/MPH.0000000000000141

Table IV.

List of Grade 3/4 Toxicities by Risk Group

Toxicity Risk Group
Intermediate High
Grade 3 Grade 4 Grade 3 Grade 4
N n n n
Hematologic Toxicities
 Anemia 4 5 1
 Total White Blood Cell count 3 3 4 2
 Neutropenia 2 5 2 5
 Thrombocytopenia 4 2
Non-hematologic Toxicities
 Elevated transanimases 1
 Allergic reaction/hypersensitivity (including drug fever) 1
 Diarrhea 1
 Dyspnea 1
 Febrile neutropenia 1 1
 Hypoxia 1
 Infection with normal ANC or Grade 1 or 2 neutrophils, Lung (pneumonia) 1
 Infection with normal ANC or Grade 1 or 2 neutrophils, Skin (cellulitis) 1
 Infection with normal ANC or Grade 1 or 2 neutrophils, Upper airway NOS 1
 Nausea 1
 Hypophosphatemia 1
 Hypokalemia 1
 Vomiting 1