Table 2.

Comparison of methods in terms of estimate, standard error of the estimate and power for GEI, under a simulation study of non-linear GEI. [IPD: individual patient data; UIVW: univariate inverse- variance weighted estimator; MIVW: multivariate inverse-variance weighted estimator; MR: Meta-regression; AWE: adaptively weighted estimator combining UIVW and MR; TS: two-stage approach.]

Methods	Estimate	SEa	Power
IPD	0.21	0.045	0.98
UIVW	0.18	0.070	0.69
MIVW	0.21	0.045	0.98
MR	0.23	0.060	0.82
AWE	0.21	0.045	0.98
TS			0.85

^aSE: standard error.