Table 1.
Sample demographics, Iowa Gambling Task (IGT) net scores, substance use disorder (SUD) outcomes, and 5-HTT-linked polymorphic region (5-HTTLPR) and catechol-O-methyltransferase (COMT) genotype in high-risk (HR) offspring and low-risk (LR) controls. Group comparisons were made using t tests for continuous variablesa and chi-square for frequency datab.
| Variable | HR (n = 63) M (SE) | LR (n = 45) M (SE) | p |
| Male/femaleb | 33/30 | 23/22 | n.s. |
| Age at study entrya | 11.38 (2.94) | 11.78 (2.55) | n.s. |
| Age at last follow-upa | 26.27 (4.92) | 25.09 (5.55) | n.s. |
| Length of follow-upa | 14.89 (5.69) | 13.31 (5.82) | n.s. |
| Age at IGT testinga | 25.35 (4.97) | 24.47 (5.60) | n.s. |
| Socioeconomic statusa | 38.79 (1.49) | 42.41 (1.76) | n.s. |
| IGT Total Net Scorea | 49.27 (8.86) | 53.33 (9.24) | .023 |
| IGT final block scorea | 47.27 (10.65) | 52.49 (11.54) | .017 |
| WMS working memorya | 21.94 (0.51) | 22.84 (0.73) | n.s. |
| Freq. (%) M (SE) | Freq. (%) M (SE) | ||
| Substance use disorderb | 39 (62%) | 9 (20%) | <.001 |
| Age at SUD onseta | 18.87 (3.02) | 20.56 (4.33) | n.s. |
| 5-HTTLPR genotypesb | |||
| LL | 10 (18%) | 8 (26%) | |
| LS | 27 (49%) | 20 (64%) | n.s. |
| SS | 18 (33%) | 3 (10%) | |
| COMT genotypesb | |||
| Val/Val | 16 (29%) | 7 (23%) | |
| Val/Met | 33 (60%) | 17 (54%) | n.s. |
| Met/Met | 6 (11%) | 7 (23%) |
Notes: n.s. = nonsignificant; freq. = frequency; WMS = Wechsler Memory Scale.