FIG. 9.

LLPS is metastable with respect to crystallization in a human IgG cryoglobulin (M31) solution. (a) LLPS in a 0.5 mg/ml IgG solution with 10.3% (w/w) PEG3k was observed by a bright field microscope at 21 °C. (b) After 8 h incubation at 21 °C, clusters of needle-like crystals emerged in the solution while the protein-rich liquid droplets were consumed.