FIG. 3.

Multi-state gene expression models and chromatin template-controlled noise in mRNA: (a) Schematic of a multi-inactive-state model of gene expression; (b) schematic of a multi-active-state model of gene expression; (c) the mean noise strength ratio ${\eta }_{multi-on}^2/{\eta }_{multi-off}^2$ as a function of two experimentally-measureable indices τ_on and τ_off, where both ${\eta }_{multi-on}^2$ and ${\eta }_{multi-off}^2$ are obtained from one of 1000 sets of randomly sampling τ₁, …, τ_K with the fixed τ_on and τ_off for the fixed K ≡ L = R = 10 (where L and R represent the number of OFF states and ON states, respectively). The other parameters are μ = 20, δ = 1, K = 10; (d), (e), and (f) shown is the histogram of ${\eta }_{multi-on}^2$ (red) and ${\eta }_{multi-off}^2$ (green), where (d), (e) and (f) correspond to points D, E and F labeled in (c), respectively.