Table 1. Studies Published Concerning the GABA Hypothesis in ET.

	CSF	Purkinje Cell Loss	Pathology GABA	Electrophysiology	Genetic	Animal Models	Imaging	Drug Therapies
Pros	Mally et al.21	Louis et al.15	Mouginot and Gahwiler20	Uusiaari and Knopfel24		Kralic et al.34	Boecket et al.35	Theophylline, 199139
		Axelrad et al.16	Paris-Robidas et al.22	Pinault and Deschenes28			Gironell et al.36	Muscimol, 199140
		Louis et al.18	Shill et al.23					Gabapentin, 199941
								Gabapentin, 200043
								Topiramate, 200245
								Topiramate, 200646
								Topiramate, 200848
								Pregabaline, 200750
Cons		Rajput et al.61			Deng et al.29			Progabide, 198337
					Thier et al.30			Progabide, 198738
		Shill et al.62			García-Martín et al.31			Gabapentin, 199942
		Symanski et al.63			García-Martín et al.32			Topiramate, 200647
								Tiagabine, 200849
								Pregabaline, 200951
								Pregabaline, 201252

CSF, Cerebrospinal Fluid; ET, Essential Tremor; GABA, gamma-aminobutyric acid.