Table 2. Levels of serum blood chemical parameters in peripheral blood before and after drug administration in male cynomolgus monkeys.
| Before | After | |
|---|---|---|
| Total protein (g/dl) | 7.1 ± 0.1 | 6.8 ± 0.3 |
| Albumin (g/dl) | 4.1 ± 0.3 | 4.0 ± 0.4 |
| Total bilirubin (mg/dl) | 0.11 ± 0.01 | 0.10 ± 0.01 |
| Cholestrol (mg/dl) | 109 ± 14 | 107 ± 14 |
| Triglycelides (mg/dl) | 28 ± 7 | 23 ± 5 |
| Alkaline phosphatase (mU/ml) | 613 ± 92 | 581 ± 89 |
| Aspartate aminotransferase (mU/ml) | 32 ± 7 | 50 ± 10 |
| Alanine aminotransferase (mU/ml) | 42 ± 13 | 42 ± 13 |
| Glucose (mg/dl) | 70 ± 3 | 65 ± 4 |
| Blood urea nitrogen (mg/dl) | 27 ± 4 | 26 ± 3 |
| Creatinine (mg/dl) | 1.0 ± 0.12 | 1.2 ± 0.14 |
| Inorganic P (mg/dl) | 5.2 ± 0.4 | 5.6 ± 0.5 |
| Ca2+ (mg/dl) | 10.0 ± 0.3 | 9.4 ± 0.3 |
| Na+ (mEq/l) | 149 ± 0.6 | 149 ± 0.5 |
| K+ (mEq/l) | 5.4 ± 0.2 | 5.4 ± 0.2 |
| Cl− (mEq/l) | 108 ± 1.2 | 110 ± 0.5 |
Me 0.02 mg/kg-Mi 0.15 mg/kg-Bu 0.2 mg/kg combination was administered intramuscularly, and 30 min after, atipamezole 0.2 mg/kg was administered. Blood sample was collected before dosing and 2 hr after i.m. administration of the Me-Mi-Bu combination. Values are means ± S.E.M. (n=4).