Table 3. Levels of hematological parameters in peripheral blood before and after drug administration in male cynomolgus monkeys.
| Before | After | |
|---|---|---|
| Red blood cell count (×106/μl) | 5.5 ± 0.2 | 5.2 ± 0.3 |
| Hemoglobin concentration (g/dl) | 13.7 ± 0.6 | 12.7 ± 0.9 |
| Hematocrit (%) | 45.3 ± 1.8 | 42.2 ± 3.1 |
| Mean corpuscular volume (fl) | 81.7 ± 1.3 | 81.1 ± 1.7 |
| Mean corpuscular hemoglobin (pg) | 24.6 ± 0.4 | 24.4 ± 0.4 |
| Mean corpuscular hemoglobin concentration (g/dl) | 30.1 ± 0.3 | 30.1 ± 0.2 |
| Red blood cell distribution width (%) | 13.0 ± 0.2 | 12.9 ± 0.2 |
| Hemoglobin concentration distribution width (g/dl) | 2.1 ± 0.1 | 2.2 ± 0.1 |
| Platelet count (×103/μl) | 448 ± 95 | 423 ± 76 |
| White blood cell count (×103/μl) | 10.9 ± 1.1 | 10.5 ± 2.4 |
Me 0.02 mg/kg-Mi 0.15 mg/kg-Bu 0.2 mg/kg combination was administered intramuscularly, and 30 min after, atipamezole 0.2 mg/kg was administered. Blood sample was collected before dosing and 2 hr after i.m. administration of the Me-Mi-Bu combination. Values are means ± S.E.M. (n=4).