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. 2014 Jul 11;15(1):587. doi: 10.1186/1471-2164-15-587

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© Tan et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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microRNA and gene microarray expression on 7 and 15 dpi. (a) Representative heatmaps of microarrays revealed that relatively fewer miRNAs and genes were differentially expressed at 7 dpi. However, more alterations in expression occurred at 15 dpi, when viral clearance was complete. In infected lung samples at both 7 and 15 dpi, the higher numbers of down-regulated miRNAs coincided with the increase in up-regulated genes. (b) Scatter plots showed negligible overlap between the differentially expressed miRNAs and genes at the two time-points, indicating that highly specific functions were operating during these two phases of influenza pneumonia. N = 4 per group per time-point.