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. 2014 Jul 11;15(1):587. doi: 10.1186/1471-2164-15-587

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© Tan et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Further refinement of miRNA selection to identify physiologically important miRNAs during repair. Integrated miRNA and gene (GO term) networks of selected miRNA candidates. (a) At 7 dpi, the network was relatively moderate, with a focus on targeting tissue development. (b) At 15 dpi, an extensive network was involved in pulmonary repair and regeneration mainly by targeting cell cycle functions. It is likely that most miRNAs were down-regulated possibly to facilitate developmental gene expression.