Fig. 1.

(A) Sagittal and (B) axial views of the voxel of interest (VOI) in the occipital cortex. The light shaded area depicts the precuneus [P], a large fraction of which can be seen to be contained within the VOI from which GSH was measured. (C) In vivo ¹H MRS acquisition of GSH, showing: (a) and (b) subspectra that are subtracted to obtain the cleanly “edited” GSH spectrum in (c); (d) frequency-domain model-fitting of only the edited GSH peak in (c) to derive its peak, which is directly proportional to the concentration of the antioxidant in the VOI; (e) residual of the difference between (c) the measured and (d) the fitted GSH spectral peak shows the “goodness of fit”. NAA, N-acetyl-l-aspartate; tCr, total creatine; tCho, total choline.