Figure 5. KS370G regulates the expression of E-cadherin and α-SMA in NRK52E and HK-2 cells induced by TGF-β₁.

(A and D) E-cadherin and α-SMA expression were determined by western blot of NRK52E and HK-2 cells cultured with different concentration of KS370G (0.1 to 3 μM) for 72 h under TGF-β₁ stimulation. (B,C,E and F) Quantitative results presented as mean ± SEM of the signal's optical density for E-cadherin (B; n = 7) and α-SMA (C; n = 5) in NRK52E cells and E-cadherin (E; n = 3) and α-SMA (F; n = 3) in HK-2 cells. *P < 0.05 compared with control group. #P < 0.05 compared with TGF-β₁ (5 ng/ml) groups.