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. Author manuscript; available in PMC: 2015 Jan 18.
Published in final edited form as: Nat Commun. 2014 Jul 18;5:4387. doi: 10.1038/ncomms5387

Figure 6.

Figure 6

Intra-tracheal instillation of rhMG53 protects PPE-induced injury to rat lung. A. PPE was applied through intra tracheal (i.t.) spray. LDH in BALF was measured 30 min after PPE application to evaluate cell damage. Different concentrations of MBP-MG53 or control proteins (denatured MBP-MG53 or BSA) were applied through intra tracheal spray 5 min before PPE. 0.2 mg/kg and 2 mg/kg MBP-MG53 significantly reduced LDH in BALF. The measurements of chronic responses were conducted 4 weeks after PPE application with repetitive application of MBP-MG53 (i.t., 5 days per week for 4 weeks). EELV (B), lung elastance (C), and alveolar structure (quantified by Lm) of the lung (D) were compared to control treatment groups. n=7-10 per group. E. Representative histology images of lung parenchyma in PPE-induced injury to rat lung with or without administration of MG53 (scale bars are equal to 200 μm). *: P<0.05 vs. saline control group (open bar). #: P<0.05 vs. denatured MBP-MG53 group (Mann-Whitney U analysis).