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. 2014 Jul 22;5:4486. doi: 10.1038/ncomms5486

Figure 1. Activated microglia target cortical neurons and displace inhibitory synapses from neuronal soma.

Figure 1

(a–c) Confocal micrographs show morphological changes of microglia (green) following multiple LPS injections. Arrowheads indicate microglia enwrapping neuronal cell bodies (red). Scale bar, 40 μm. (d) Quantification of the percentage of microglia in contact with neurons. N=3 per group. (e,f) Triple labelling of microglia (blue), neurons (red) and GAD+ inhibitory synapses (green). Scale bar, 10 μm. (g) Quantification of the percentage of neuronal circumference occupied by inhibitory synapses over the indicated time course. N=31 to 55 neurons sampled from six individual mice per group. Error bars represent s.e.m. *P<0.05; **P<0.01 compared with control group using a one-way ANOVA test.