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. 2014 Jul 22;5:4486. doi: 10.1038/ncomms5486

Figure 4. Increased neuronal synchronization is associated with increased phosphorylation of CREB.

Figure 4

(a) Comparison of total and phosphorylated forms of CREB, CaMKIV, ERK1/2 and Akt in cortices from PBS-injected mice at 1DPI (control) and LPS-injected mice at 1 or 14 DPI. GAPDH was used as protein loading controls. Full western blot images are shown in Supplementary Fig. 6. (b) Densitometry quantification of a with the relative intensity of the controls set as 100%. (c) Immunohistochemistry demonstrates the enrichment of pCREB, CaMKIV and ERK1/2 in cortical neurons of LPS-injected mice at 1 DPI. Data are presented as mean+s.e.m. *P<0.05, **P<0.01; one-way ANOVA. Scale bar, 40 μm.