Table 2.
Results from 13 Multivariable Linear Regression Models (One for Each Medication) with Intraocular Pressure as the Dependent Variable
| β | 95% CI | P value | |
|---|---|---|---|
| ACE inhibitors | −0.03 | (−0.26, 0.19) | 0.76 |
| Angiotensin receptor blockers | 0.07 | (−0.27, 0.40) | 0.69 |
| α-Blockers | −0.15 | (−0.49, 0.19) | 0.40 |
| β-Blockers | −1.04 | (−1.30, −0.79) | <0.001 |
| Calcium channel blockers | −0.13 | (−0.38, 0.13) | 0.32 |
| Diuretics | −0.03 | (−0.27, 0.20) | 0.77 |
| Nitrates | −1.04 | (−1.51, −0.58) | <0.001 |
| Statins | −0.29 | (−0.50, −0.09) | 0.003 |
| Insulin | −0.34 | (−1.29, 0.62) | 0.49 |
| Biguanides | 0.13 | (−0.46, 0.71) | 0.67 |
| Sulfonylureas | 0.45 | (−0.25, 1.16) | 0.21 |
| Aspirin | −0.42 | (−0.64, −0.20) | <0.001 |
| NSAIDs excluding aspirin | −0.05 | (−0.35, 0.24) | 0.72 |
ACE = angiotensin converting enzyme; NSAIDs = nonsteroidal anti-inflammatory drugs.
All models were adjusted for age, gender, and body mass index. Models for diabetic medication (insulin, biguanides, and sulfonylureas) were further adjusted for blood glycosylated hemoglobin level.
P<0.0038 appear in boldface, and reflect a 5% significance level adjusted for multiple comparisons using the Bonferroni correction.