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. Author manuscript; available in PMC: 2014 Jul 24.
Published in final edited form as: J Pharmacol Sci. 2008 Sep 11;108(1):144–148. doi: 10.1254/jphs.08100sc

Fig. 1.

Fig. 1

Time-dependent expression of intestinal drug transporters. Plots of relative mRNA signal against time for Mdr1 multidrug resistance like protein 1 (A), Mrp2 multidrug resistance protein 2 (B), Mct1 monocarboxylate transporter 1 (C), Pept1 peptide transporter 1 (D), and Bcrp breast cancer resistance protein (E). All show both significance on ANOVA between time points (* compared to # P<0.05 and an overall significant rhythm on cosinor analysis. In contrast, panel F shows expression of Oatp-b organic anion transporter B, which shows no significant variation on either ANOVA or cosinor analysis. The first time point (Zeitgeber time ZT0) has been repeated at ZT24 to complete the cycle.