(a) NOEs characteristic of 12/10 helix formation. (i) NOEs observed in α/γ-peptides 9, 12, and 15 consistent with those reported for the α/γ-peptide 12/10-helix by Sharma and Kunwar.11 (ii) NOE observed in our study of α/γ-peptides 9, 12, and 15. (iii) NOE observed in 12/10 helical peptides of Sharma and Kunwar - not observed in NMR study of 9, 12, and 15. (b) Diagram of hydrogen bonding in the α/γ-peptide 12/10-helix. γ-residues shown in green.