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(A) Mechanism of catalysis of DOT1L; (B) The overall structure of human DOT1L(1-416) in complex with SAM (ball & stick model with C atoms in green); (C) The close-up view of the active site of the DOT1L:SAM structure, with H-bonds shown as dotted lines; (D) The close-up view of the lysine binding channel, with the methyl group of SAM shown in ball & stick model.
