Figure 1.

Podocytes form complex communication networks with their environment and are in constant contact with a variety of signal sources and receivers, including other glomerular cell types and the extracellular matrix. They also signal to neighbouring podocytes, enabling coordination of podocyte function in the glomerulus. Podocytes are exposed to a myriad of potential signalling molecules present in the circulation as well as biophysical cues, such as changes in blood pressure.