Table 2.
Cross-associations of CYP19A1 genotypes with IL6 and NFκB1 gene expression in colon and liver samples
| CYP19A1 SNPs | Frequency (n) | Median (2^ΔCt) | Fold change | P-value* |
|---|---|---|---|---|
| (A) NFκB1 expression in colon | ||||
| rs12908960 | ||||
| GG/GA | 65 | 0.079 | 2.0 | 0.047 |
| AA | 13 | 0.040 | ||
| rs730154 | ||||
| AA | 39 | 0.052 | 1.6 | 0.036 |
| AG/GG | 39 | 0.085 | ||
| rs8025191 | ||||
| AA | 51 | 0.085 | 1.7 | 0.051 |
| AG/GG | 27 | 0.050 | ||
| rs17523880 | ||||
| CC | 51 | 0.082 | 1.8 | 0.031 |
| CA/AA | 27 | 0.045 | ||
| (B) IL6 expression in colon | ||||
| rs11856927 | ||||
| TT/TG | 61 | 0.0031 | 3.1 | 0.049 |
| GG | 16 | 0.0094 | ||
| rs2470152 | ||||
| CC/CT | 65 | 0.0033 | 3.7 | 0.025 |
| TT | 12 | 0.0121 | ||
| rs2470144 | ||||
| GG | 33 | 0.0023 | 3.4 | 0.047 |
| GA/AA | 44 | 0.0079 | ||
| (C) IL6 expression in liver | ||||
| rs12908960 | ||||
| GG | 67 | 0.0149 | 3.5 | 0.004 |
| GA/AA | 106 | 0.0043 | ||
| rs2470144 | ||||
| GG | 66 | 0.0145 | 2.2 | 0.022 |
| GA/AA | 139 | 0.0066 | ||
Note:
*
Nonparametric analysis of variance (Kruskal–Wallis or Wilcoxon rank sums test).
Abbreviations: IL6, interleukin-6; SNPs, single nucleotide polymorphisms; NFκB, nuclear factor kappa-light-chain-enhancer of activated B-cells.