Table 3.
Association of haplotypes of CYP19A1 SNPs with selected gene expression in colon
| CYP19A1 SNPs | Frequency | Median (2^ΔCt) | SD | P-value* |
|---|---|---|---|---|
| (A) CYP19A1 expression | ||||
| rs10459592 T>G | ||||
| rs1961177 C>T | ||||
| rs6493497 G>A | ||||
| Haplotype | ||||
| TTA | ||||
| 0 copy† | 0.80 | 1.8E-4 | 0.009 | 0.003 |
| 1 copy | 0.20 | 4.8E-5 | 0.0002 | |
| (B) NFκB1 expression | ||||
| rs12908960 G>A | ||||
| rs730154 A>G | ||||
| rs17523880 C>A | ||||
| rs8025191 A>G | ||||
| Haplotype | ||||
| GGCA | ||||
| 0 copy | 0.51 | 0.048 | 0.099 | 0.049 |
| 1 copy | 0.37 | 0.085 | 0.134 | |
| 2 copies | 0.12 | 0.114 | 0.126 | |
| (C) IL6 expression | ||||
| rs11856927 T>G | ||||
| rs2470152 C>T | ||||
| rs2470144 G>A | ||||
| Haplotypes | ||||
| TCG | ||||
| 0 copy | 0.71 | 0.0078 | 0.151 | 0.011 |
| 1 copy | 0.29 | 0.0019 | 0.018 | |
| GCG | ||||
| 0 copy | 0.78 | 0.0047 | 0.123 | 0.053 |
| 1 copy | 0.16 | 0.0014 | 0.010 | |
| 2 copies | 0.06 | 0.067 | 0.273 | |
Notes: Haplotypes created based on results from colon samples;
*
Nonparametric analysis of variance (Kruskal–Wallis or Wilcoxon rank sum test);
†
0 copy, no copies of the haplotype; 1 copy, one copy of the haplotype; 2 copies, two copies of the haplotype.
Abbreviations: IL6, interleukin-6; SNPs, single nucleotide polymorphisms; NFκB, nuclear factor kappa-light-chain-enhancer of activated B-cells; SD, standard deviation.