Table S3.

Association of haplotypes of CYP19A1 SNPs with selected gene expression in colon

CYP19A1 SNPs	Frequency	Median (2ΔCT)	SD	P-value*
(A) CYP19A1 expression
rs10459592 T>G
rs1961177 C>T
rs6493497 G>A
Haplotype
GCG
0 copy	0.31	0.00120	0.00408	0.38
1 copy	0.50	0.00267	0.01049
2 copies	0.19	0.00070	0.00091
TCG
0 copy	0.40	0.00110	0.00364	0.72
1 copy	0.44	0.00303	0.01111
2 copies	0.16	0.00040	0.00052
TTA
0 copy	0.80	0.00227	0.00863	0.0038
1 copy	0.17	0.00011	0.00019
2 copies	0.03	0.00031	0.00028
(B) NFκB1 expression
rs12908960 G>A
rs730154 A>G
rs17523880 C>A
rs8025191 A>G
Haplotype
GGCA
0 copy	0.51	0.08794	0.09937	0.049
1 copy	0.37	0.12575	0.13461
2 copies	0.12	0.15026	0.12619
AACA
0 copy	0.60	0.09295	0.08635	0.09
1 copy	0.35	0.14648	0.15756
2 copies	0.05	0.04831	0.05116
GACA
0 copy	0.63	0.11540	0.12490	0.79
1 copy	0.34	0.09895	0.10657
2 copies	0.03	0.09522	0.10883
AAAG
0 copy	0.83	0.11841	0.12471	0.22
1 copy	0.15	0.06508	0.05379
2 copies	0.02	0.03880	0.0001
AAAA
0 copy	0.85	0.11301	0.12282	0.84
1 copy	0.15	0.08815	0.08215
(C) IL6 expression
rs11856927 T>G
rs2470152 C>T
rs2470144 G>A
Haplotype
TTG
0 copy	0.53	0.03375	0.10986	0.98
1 copy	0.43	0.05958	0.15508
2 copies	0.04	0.05123	0.08554
TCG
0 copy	0.71	0.6040	0.15092	0.025
1 copy	0.25	0.00934	0.01893
2 copies	0.04	0.00138	0.00166
GCA
0 copy	0.57	0.04007	0.10889	0.34
1 copy	0.38	0.04857	0.15764
2 copies	0.05	0.08305	0.14872
GCG
0 copy	0.77	0.04360	0.12301	0.053
1 copy	0.16	0.00644	0.00988
2 copies	0.07	0.16209	0.27339
TTA
0 copy	0.81	0.04673	0.13932	0.58
1 copy	0.19	0.04045	0.08229
TCA
0 copy	0.92	0.04811	0.13478	0.44
1 copy	0.08	0.01465	0.01784
GTG
0 copy	0.92	0.04869	0.13469	0.84
1 copy	0.08	0.00778	0.00644

Notes: Haplotypes created based on results from colon samples:

^*non-parametric ANOVA (Kruskal–Wallis or Wilcoxon rank sums test).

Abbreviations: SNPs, single nucleotide polymorphisms; IL6, interleukin-6; NFκB, nuclear factor kappa-light-chain-enhancer of activated B-cells; SD, standard deviation.