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. 2014 Jul 7;2014:741309. doi: 10.1155/2014/741309

Figure 3.

Figure 3

Antibodies against Rv2241, Rv0009, Rv0407, and Rv2624c recombinant proteins in drug-sensitive and MDR-TB patients' sera. ELISA plates were coated with recombinant proteins, loaded with 1/500 serum dilutions, and reveled with HRP conjugated anti-human polyvalent IgM/A/G. (a) 1D scatter plots indicating serological results of No-TB (No TB, n = 31), drug-sensitive TB (S TB, n = 19), and multi-drug-resistant TB (MDR TB, n = 18) patients' sera. Threshold, defined by maximum likelihood ratio (ROC analysis), was shaded in gray. Seropositive samples for each protein were color highlighted (Rv2241 = red, Rv0009 = purple, Rv0407 = blue, and Rv2624c = green). (b) ROC analysis indicating area under curve ± 95% CI. (c) Correlation analysis between signals (mean ± SEM) of positive samples versus immune-informatics predicted epitope density (median ± range) for each recombinant protein.